abstract：:The aim was to analyze morphologico-functional characteristics of ductal carcinoma in situ (DCIS) in breast MRI to assess signs correlating with the degree of nuclear atypia. From 636 malignant lesions, 114 were DCIS (17.92%): 44 cases of high-grade (38.60%), 37 intermediate (32.45%), 33 low-grade (28.95%). MRI charac...

journal_title：Neoplasma

authors： Lehotska V,Rauova K,Vanovcanova L

更新日期：2018-03-14 00:00:00

abstract：:HCC is one of the leading causes of death worldwide. Liver transplantation including living donor transplantation is the best available treatment. We have analyzed our experience with LDLT in patients with HCC and HCV in order to determine if alpha feto-protein (AFP) is a better predictor of recurrence than the tumor ...

journal_title：Neoplasma

authors： Komorowski AL,Hsu CC,Julka KD,Vasavada B,Lin CC,Wang CC,Chen CL

更新日期：2018-03-14 00:00:00

abstract：:This study was supposed to investigate the correlation between the functional single nucleotide polymorphisms (SNPs) (rs2516839 and rs3737787) in USF1 gene and the efficacy and safety of paclitaxel-based chemotherapy and prognosis in the treatment of ovarian cancer (OC). In total 100 OC patients were selected and divi...

journal_title：Neoplasma

authors： Ye H,Liu XJ,Hui Y,Liang YH,Li CH,Wan Q

更新日期：2018-01-01 00:00:00

abstract：:HCC (hepatocellular carcinoma), which can be induced by cirrhosis and viral hepatitis infection, is the most frequent form of liver cancer. This study is performed to investigate the mechanisms of HCC. GSE57957 was obtained from Gene Expression Omnibus database, including 39 HCC samples and 39 adjacent non-tumorous sa...

journal_title：Neoplasma

authors： Shi SQ,Ke JJ,Xu QS,Wu WQ,Wan YY

更新日期：2018-01-01 00:00:00

abstract：:We aimed to investigate the role of FUT1 gene in Taxol resistance and to explore its mechanism in epithelial ovarian cancer. Three ovarian cancer cell lines, ES-2, SK-OV-3 and OVCAR-3 were selected from epithelial ovarian cancer in this experiment. Western blot was used to validate the protein expression level of FUT1...

journal_title：Neoplasma

authors： Li FF,Sha D,Qin XY,Li CZ,Lin B

更新日期：2018-01-01 00:00:00

abstract：:Patients with clinically node-positive bladder cancer have a poor prognosis, with many receiving only palliative chemo- therapy. We evaluated oncological results in bladder cancer patients with clinically regional and supraregional lymph- adenopathy treated with induction chemotherapy (IC) and consolidative cystectomy...

journal_title：Neoplasma

authors： Stanik M,Poprach A,Macik D,Capak I,Maluskova D,Mareckova N,Lakomy R,Jarkovsky J,Dolezel J

更新日期：2018-01-01 00:00:00

abstract：:Metadherin (MTDH) is an oncoprotein and is expressed at high levels in a wide variety of human carcinomas, which represents an important genetic determinant and regulates multiple events in tumorigenesis. MTDH promotes breast cancer cell proliferation and tumorigenesis through the activation of numerous signaling path...

journal_title：Neoplasma

authors： Chen X,Li XY,Long M,Wang X,Gao ZW,Cui Y,Ren J,Zhang Z,Liu C,Dong K,Zhang H

更新日期：2018-01-01 00:00:00

abstract：:Although Flotillin 1 (FLOT1) is highly expressed in various human cancers, its relationship with ovarian cancer (OC) remains unknown. This study determines FLOT1 expression in human ovarian tumors and examines its effect on OC   cell proliferation. FLOT1 protein expression was assessed in a tissue microarray by immuno...

journal_title：Neoplasma

authors： Li J,Zuo X,Shi J,Zhang J,Duan X,Xu G

更新日期：2018-01-01 00:00:00

abstract：:Functional microRNA (miRNA) molecules are transported in extracellular vesicles among tumor cells and cells of the immune system. Macrophages as integral components of tumor microenvironment are known as potential contributors to tumor growth and progression. We searched for studies which could provide a direct link b...

journal_title：Neoplasma

authors： Korabecna M,Koutova L,Tesarova P

更新日期：2017-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of newly-identified non-coding RNA molecules. CircRNAs are conserved across different species and display specific organization, sequence, and expression in disease. Moreover, circRNAs' closed ring structure, insensitivity to RNase, and stability are advantages over linear RNAs in ...

journal_title：Neoplasma

authors： Zheng XB,Zhang M,Xu MQ

更新日期：2017-01-01 00:00:00

abstract：:We investigate the clinical characteristics, prognosis and treatment of relapsed and refractory Hodgkin's lymphoma. Twenty patients with relapsed and refractory Hodgkin lymphoma were treated by chemotherapy or autologous stem cell transplantation in our hospital from April 2006 to August 2012. The retrospective analys...

journal_title：Neoplasma

authors： Yang HL,Zhang YZ,Jiang YZ,Wang XF,Cao Z

更新日期：2017-01-01 00:00:00

abstract：:Knowledge of biological properties of natural compounds allows to understand their therapeutic value, efficacy and security. We investigated: composition of Lavandula angustifolia (LA) and Rosmarinus officinalis (RO) extracts, their antioxidant capacity, cytotoxicity and genotoxicity, their DNA-protective potential ag...

journal_title：Neoplasma

authors： Horvathova E,Kozics K,Melusova M,Galova E,Sevcovicova A,Kusznierewicz B,Chmiel T,Slamenova D

更新日期：2017-01-01 00:00:00

abstract：:Research indicates that after EGFR-tyrosine kinase inhibitors (EGFR-TKIs) treatment of non-small cell lung cancer (NSCLC), patient immune function significantly improved, and that circulating tumor cells (CTCs) measurements and peripheral blood epidermal growth factor receptor (EGFR) mutation data can guide TKIs treat...

journal_title：Neoplasma

authors： Tu C,Zhu Y,Jiang B,He W,Jin C

更新日期：2017-01-01 00:00:00

abstract：:MiR-34a acts as a tumor suppressor in various malignancies. In HNSCC, the role of miR-34a in proliferation has not been fully elaborated and the target genes are still bind. Here, we addressed that forced miR-34a expression induced cell cycle arrest and senescence. Hypoxia/HIF1α was found to negatively correlate to th...

journal_title：Neoplasma

authors： Wang Y,Chen J,Chen X,Jiang F,Sun Y,Pan Y,Zhang W,Zhang J

更新日期：2017-01-01 00:00:00

abstract：:In the presented study we analysed the effect of histone deacetylase inhibitors (HDACi) suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) on human plasma cell leukemia (PCL) cell line UHKT-944 in the presence of bone marrow microenvironment (BMM). For the analysis, the cells were cultured alone, with bone...

journal_title：Neoplasma

authors： Burianova I,Kuzelova K,Mitrovsky O,Spicka I,Stockbauer P,Zackova M

更新日期：2017-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. Although advances have made in treatment of HCC, the overall survival rate remains low and the molecular pathogenesis of HCC is still poorly understood. The purpose of this study was to explore the molecular pathogenesis of HCC. ...

journal_title：Neoplasma

authors： Huang H,Wang X,Wang C,Zhuo L,Luo S,Han S

更新日期：2017-01-01 00:00:00

abstract：:Lung cancer has been a major threat to human health worldwide. Vimentin (VIM) and E-cadherin (E-cad) are molecular markers that play important roles in epithelial-mesenchymal transition (EMT), which has been shown to be correlated with tumor progression. Herein, we investigated the associations between clinicopatholog...

journal_title：Neoplasma

authors： Luo T,Wang L,Wu P,Gong W,Chen W,Zhao H,Zheng Z

更新日期：2017-01-01 00:00:00

abstract：:To explore how Tim-3 is expressed and how its expression influences invasion and metastasis of colorectal cancer (CRC) cells. A total of 188 CRC patients were prospectively collected for this study. Meanwhile, 135 normal controls were incorporated during the same period. Intestinal samples of the CRC radical cancerous...

journal_title：Neoplasma

authors： Sun QY,Qu CH,Liu JQ,Zhang P,Yao J

更新日期：2017-01-01 00:00:00

abstract：:We report in this study that microRNA-584-3p (miR-584-3p) is related to the vasculogenic mimicry (VM) of human glioma cells. Unsurprisingly, the postoperative survival time was significantly prolonged in those glioma patients without VM phenomena compared with those with positive VM. miR-584-3p may function as a poten...

journal_title：Neoplasma

authors： Xu S,Zhang J,Xue H,Guo X,Han X,Li T,Guo X,Gao X,Liu Q,Li G

更新日期：2017-01-01 00:00:00

abstract：UNLABELLED:Antiangiogenic drugs are approved for many cancer types for longer than a decade. Furthermore, several antiangiogenic agents are approved for local application in ophthalmology for treatment of macular degeneration, venous retinal occlusion and diabetic retinopathy. Knowing that antiangiogenic agents are act...

journal_title：Neoplasma

authors： Cernak M,Nogova L

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present retrospective study was to evaluate the prognostic significance of epidermal growth factor receptor (EGFR) expression in patients treated with radiotherapy or concomitant chemoradiotherapy for squamous cell anal cancer (SCAC)Patients and methods: A total of 17 patients with SCAC (clinical stages...

journal_title：Neoplasma

authors： Richter I,Jirasek T,Dvorak J,Cermakova E,Bartos J

更新日期：2016-01-01 00:00:00

abstract：:An actin-binding protein filamin A connects the actin filament network to cell membrane receptors, and acts as a scaffold for various signaling pathways related to cancer growth and progression. Recently, it has been reported that filamin A is required for efficient regulation of early stages of DNA repair process. Mo...

journal_title：Neoplasma

authors： Gachechiladze M,Skarda J,Janikova M,Mgebrishvili G,Kharaishvili G,Kolek V,Grygarkova I,Klein J,Poprachova A,Arabuli M,Kolar Z

更新日期：2016-01-01 00:00:00

abstract：:Extracellular adenosine is a key signaling molecule which mediates immune suppression, angiogenesis, and regulates cancer cells growth. The effect of adenosine on cervical cancer cells migration and invasion has not been well studied. In the current study, we used Hela and SiHa cell lines to evaluate the effects of ad...

journal_title：Neoplasma

authors： Gao ZW,Wang HP,Dong K,Lin F,Wang X,Zhang HZ

更新日期：2016-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a rare malignancy in the Czech Republic and Slovakia, with the standardized incidence rate of < 1:100000 person-years. Viral status of NPC in these non-endemic Eastern European regions is currently unknown. In a retrospective study, we evaluated the presence of EBV and HPV in 62 NPC c...

journal_title：Neoplasma

authors： Svajdler M Jr,Kaspirkova J,Mezencev R,Laco J,Torday T,Dubinsky P,Straka L,Ondic O,Michal M,Skalova A

更新日期：2016-01-01 00:00:00

abstract：:Circulating tumor cells (CTCs) represent a potential non-invasive substitute for real-time tissue biopsy. Moreover, detection of CTCs in breast cancer patients has been reported as a strong prognostic factor. Biomarkers on CTCs have been analysed and correlated to tissue biopsies from breast cancer patients. Discordan...

journal_title：Neoplasma

authors： Bystricky B,Mego M

更新日期：2016-01-01 00:00:00

abstract：:We report on a simple iron oxide (Venofer) labeling procedure of dental pulp mesenchymal stem cells (DP-MSCs) and DP-MSCs transduced with yeast cytosinedeaminase::uracilphosphoribosyltransferase (yCD::UPRT-DP-MSCs). Venofer is a drug approved for intravenous application to treat iron deficiency anemia in patients. Ven...

journal_title：Neoplasma

authors： Altanerova U,Benejova K,Altanerova V,Tyciakova S,Rychly B,Szomolanyi P,Ciampor F,Cihova M,Repiska V,Ondicova K,Mravec B,Altaner C

更新日期：2016-01-01 00:00:00

abstract：:Helicase POLQ-like (HELQ), an ATP-dependent 3'-5' DNA helicase, plays pivotal roles in DNA processing, such as DNA replication, recombination and repair. The recent discovery of HELQ in mouse model and human cancer cell reveal that genetic alteration of HELQ is involved in cancer susceptibility and subfertility. Here ...

journal_title：Neoplasma

authors： Han X,Zhao L,Li X

更新日期：2016-01-01 00:00:00

abstract：:Addition of trastuzumab to chemotherapy is the cornerstone of adjuvant treatment of early HER2 positive breast cancer. Clinical trials and metaanalyses of adjuvant trastuzumab have shown significant reduction in risk of recurrence and death. Nevertheless, the real magnitude of the effect of any drug must be reevaluate...

journal_title：Neoplasma

authors： Ban M,Viculin J,Tomic S,Capkun V,Strikic A,Mise BP,Utrobicic I,Vrdoljak E

更新日期：2016-01-01 00:00:00

abstract：:Expression of microRNA-129-5p (miR-129-5p) has been reported to decrease in gastric cancer (GC). However, little information is available about how miR-129-5p affects cell migration and invasion of GC. Cancer samples and matched non-tumor adjacent tissues were obtained from patients with GC. Besides, peripheral blood ...

journal_title：Neoplasma

authors： Jiang Z,Wang H,Li Y,Hou Z,Ma N,Chen W,Zong Z,Chen S

更新日期：2016-01-01 00:00:00

abstract：:Mortality rate from bladder cancer in Europe is the highest in its Central Region. This study is an attempt to find underlying factors by proper characterisation of large cohort of Polish patients with bladder cancer.This is a multicentre study enrolling 1360 consecutive patients diagnosed with primary urothelial carc...

journal_title：Neoplasma

authors： Poletajew S,Biernacki R,Buraczynski P,Chojnacki J,Czarniecki S,Gajewska D,Pohaba T,Sondka J,Skrzypczyk M,Suchojad T,Wojtkowiak D,Zaforemski B,Zapala L,Zemla A,Radziszewski P

更新日期：2016-01-01 00:00:00

abstract：:Presented study aimed to prepare A10 aptamer-modified poly (D,L-lactic-co-glycolic acid) (PLGA) nanoparticles loaded with triplex forming oligonucleotides(TFO) for targeted prostate cancer therapy. We first synthesized a PLGA-PEG-Apt copolymer. The PLGA-PEG-Apt nanoparticles (NP-Apt) were loaded with TFO using double ...

journal_title：Neoplasma

authors： Jiao J,Zou Q,Zou MH,Guo RM,Zhu S,Zhang Y

更新日期：2016-01-01 00:00:00

abstract：:The clinical significance of thymosin β4 (Tβ4) expression in bladder transitional cell carcinoma (BTCC) remains unclear. The present study assessed the relationship between the expression of Tβ4 protein and the clinicopathological features, as well as the prognosis of bladder cancer patients. Tβ4 protein expression in...

journal_title：Neoplasma

authors： Wang ZY,Zhang W,Yang JJ,Song DK,Wei JX,Gao S

更新日期：2016-01-01 00:00:00

abstract：:Very few studies have determined the prognostic value of interim and restaging PET/CT in patients with Hodgkin lymphoma using current standard of care therapy outside clinical trials. We analyzed the effect of the results of interim and restaging PET/CT on the survival (overall- and relapse-free) in patients who recei...

journal_title：Neoplasma

authors： Miltenyi Z,Barna S,Garai I,Simon Z,Jona A,Magyari F,Gergely M,Nagy Z,Keresztes K,Pettendi P,Illes A

更新日期：2015-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a particularly lethal form of cancer. Overall survival evenafter liver surgery is unsatisfactory due to high metastatic capacity and recurrence rates. Cancer stem cells (CSCs) were recently proposed to elucidate the molecular mechanism of HCC metastasis and recurrence. In our study, w...

journal_title：Neoplasma

authors： Zhao J,Xu G,Qian YW,Li YW

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the prognostic potential of the World Health Organization (WHO) 2010 grading system in patients with pancreatic insulinomas. This was a retrospective study that analyzed the overall survival of 85 pancreatic insulinoma patients treated at our Institute between May 2002 and Mar...

journal_title：Neoplasma

authors： Wang L,Yang M,Zhang Y,Xu S,Tian BL

更新日期：2015-01-01 00:00:00

abstract：:Flavopiridol, a cyclin-dependent kinase inhibitor (CDKI), shows promising anti-tumor activity in hematologic malignancies. However, Flavopiridol-induced protective autophagy may lead to drug resistance. Here we found that Hsp90 inhibitor 17-AAG can sensitize mantle cell lymphoma (MCL) cells to flavopiridol by suppress...

journal_title：Neoplasma

authors： Xiao Y,Guan J

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:Farnesoid X Receptor (FXR) and its co-partners Retinoid X Receptors (RXRs) are considered to participate in crucial biochemical and cellular processes, being involved in the pathogenesis of several diseases, including cancer. The present study aimed to evaluate the clinical significance of FXR alone and in c...

journal_title：Neoplasma

authors： Giaginis C,Koutsounas I,Alexandrou P,Zizi-Serbetzoglou A,Patsouris E,Kouraklis G,Theocharis S

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:microRNA-24 has been reported to participate in tumorgenesis and progression by several signaling pathways in various tumors. However, its potential as a serum diagnostic factor and predictive biomarker for esophageal squamous cell carcinoma (ESCC) has not been studied. In the present study, serum samples we...

journal_title：Neoplasma

authors： Dong W,Li B,Wang Z,Zhang Z,Wang J

更新日期：2015-01-01 00:00:00

abstract：:PMP22 is recently recognized as a key player in a variety of prevalent cancers. In this study, we sought to explore the correlation of peripheral myelin protein 22 (PMP22) expression with cell proliferation, invasion and apoptosis in lung cancer cell line. miR29 was transfected into Anip973 lung adenocarcinoma cell li...

journal_title：Neoplasma

authors： Qu H,Zhu M,Tao Y,Zhao Y

更新日期：2015-01-01 00:00:00

abstract：:This study aimed to identify the oncogenes associated with lung cancer based on the mRNA and single nucleotide polymorphism (SNP) profile data. The mRNA expression profile data of GSE43458 (80 cancer and 30 normal samples) and SNP profile data of GSE33355 (61 pairs of lung cancer samples and control samples) were down...

journal_title：Neoplasma

authors： Wang Y,Mei Q,Ai YQ,Li RQ,Chang L,Li YF,Xia YX,Li WH,Chen Y

更新日期：2015-01-01 00:00:00